Skip to main content
. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Bioorg Med Chem. 2011 Mar 12;19(8):2557–2564. doi: 10.1016/j.bmc.2011.03.019

Scheme 1.

Scheme 1

Synthesis of G3-OH 3, G3-MTX 4, G3-FI 5, and G3-FI-MTX 6.

Reagents and conditions: (a) DMSO, rt, overnight; (b) MTX, 2-chloro-1-methylpyridinium iodide, 4-(dimethylamino)pyridine, DMSO, rt, overnight; (c) FI, 2-chloro-1-methylpyridinium iodide, 4-(dimethylamino)pyridine, DMSO, rt, overnight; (d) G3-MTX, FI, 2-chloro-1-methylpyridinium iodide, 4-(dimethylamino)pyridine, DMSO, rt, overnight.