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. 2011 Jun 2;2(7):1828–1835. doi: 10.1364/BOE.2.001828

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©2011 Optical Society of America

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.

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Fig. 3 — Optical microscopy images demonstrating enhanced uptake of targeted silica-coated gold nanorods (SiO₂-AuNRs). a) SiO₂-AuNRs targeted to the EGFR receptor are uptaken in greater amounts in A431 cells in comparison to b) non-targeted SiO₂-AuNRs with an identical aspect ratio. Likewise, d) SiO₂-AuNRs targeted to the EGFR show increased uptake in A431 cells in comparison to e) non-targeted SiO₂-AuNRs. Cells which have not been exposed to SiO₂-AuNRs are shown in panel c) and panel f) as controls. Images obtained using a 20 × objective (0.5 NA) and Leica 6000 DM microscope.