Effect of shear stress on architecture of catheter-associated Candida biofilms. Panels show orthogonal confocal images of Candida biofilms exposed to (a, c, e) no flow or (b, d, f) shear stress for (a, b) 90 min, (c, d) 6 h, or (e, f) 24 h. Magnification ×20. Arrows indicate side view for each panel, which was used to determine biofilm thickness.