Table 1. Summary of Nuclear YAP1 Immunohistochemistry in Brain Tumors.
| Tumor | WHO grade | Total (N) |
Extent of staining (% nuclei positive) * |
Negative staining (#) |
Negative (%) |
Low YAP1 (#) |
Low YAP1 (%) |
High YAP1 (#) |
High YAP1 (%) |
|---|---|---|---|---|---|---|---|---|---|
| Embryonal Tumors | |||||||||
| Medullo. (Classic) | IV | 20 | 73 | 16 | 80 | 0 | 0 | 4 | 20 |
| Medullo. with Anaplasia | IV | 19 | 20 | 13 | 68 | 3 | 16 | 3 | 16 |
| Medullo. (Nodular) | IV | 18 | 65 | 7 | 33 | 0 | 0 | 12 | 67 |
| ATRT | IV | 3 | 80 | 0 | 0 | 0 | 0 | 3 | 100 |
| CNS PNET | IV | 4 | 90 | 1 | 25 | 0 | 0 | 3 | 75 |
| Medulloepithelioma | IV | 2 | 78 | 0 | 0 | 0 | 0 | 2 | 100 |
| Astrocytic Tumors | |||||||||
| Pilocytic Astrocytoma | I | 72 | 24 | 50 | 69 | 13 | 18 | 9 | 13 |
| Diffuse Astrocytoma | II | 9 | 14 | 0 | 0 | 7 | 78 | 2 | 22 |
| Anaplastic Astrocytoma | III | 15 | 39 | 0 | 0 | 3 | 20 | 12 | 80 |
| Glioblastoma | IV | 91 | 40 | 18 | 20 | 22 | 24 | 51 | 56 |
| Pediatric GBM | IV | 35 | 33 | 9 | 26 | 12 | 34 | 14 | 40 |
| Adult GBM | IV | 56 | 44 | 9 | 16 | 10 | 18 | 37 | 66 |
| Oligodendroglial Tumors | |||||||||
| Oligodendroglioma | II | 5 | 25 | 0 | 0 | 1 | 20 | 4 | 80 |
| Anaplastic Oligodendroglioma | III | 3 | 13 | 1 | 33 | 1 | 33 | 1 | 33 |
| Oligoastrocytic Tumors | |||||||||
| Oligoastrocytoma | II/III | 3 | 33 | 0 | 0 | 1 | 33 | 2 | 67 |
| Total | 264 | 105 | 40 | 51 | 19 | 108 | 41 |
*
Mean percent nuclei positive in YAP1-positive tumors within each tumor subtype. “negative staining” = no nuclear staining in tumor cells; “low” = 1-10% of tumor nuclei positive; “high” = > 10 percent of tumor nuclei positive for YAP1; ATRT=atypical teratoid/rhabdoid tumor; CNS PNET=Central nervous system primitive neuroectodermal tumor, GBM=Glioblastoma; Medullo. = medulloblastoma; WHO = World Health Organization.