Table 2.
A/California/07/2009 HA region | Peptide Epitope Sequence | Predicted binding restriction to HLA-DRB1 alleles (top 5% score) | |||||||
---|---|---|---|---|---|---|---|---|---|
101 | 301 | 401 | 701 | 801 | 1101 | 1301 | 1501 | ||
36–53 | VLEKNVTVTHSVNLLEDKa | x | X | X | x | X | X | x | |
43–60 | VTHSVNLLEDKHNGKLCK | X | X | X | X | ||||
113–132 | IDYEELREQLSSVSSFERFE | X | X | X | X | X | X | X | |
359–376 | TGMVDGWYGYHHQNEQGS | x | x | x | x | ||||
394–411 | NKVNSVIEKMNTQFTAVG | X | X | X | X | x | X | ||
436–453 | WTYNAELLVLLENERTLD | X | X | X | X | X | X | X | X |
441–460 | ELLVLLENERTLDYHDSNVK | X | x | X | X | X | X | X | |
461–480 | NLYEKVRSQLKNNAKEIGNG | X | X | X | X | X | X | X | X |
527–549 | IYQILAIYSTVASSLVLVVSLGA | X | X | X | X | X | X | X | X |
530–541 | ILAIYSTVASSL | X | X | X | X | X |
Whole-peptide binding predictions for HLA-DRB1 alleles are shown. Peptides are scored according to their potential to bind a particular allele. Scores in the top 5th percentile are marked with an X: a large X denotes binding of the peptide is enhanced by the core 9-mer binding peptides shown in Table 1; a small X indicates predicted binding without the contribution of a core 9-mer peptide.