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. Author manuscript; available in PMC: 2011 Jul 6.
Published in final edited form as: Vaccine. 2011 Feb 22;29(17):3299–3309. doi: 10.1016/j.vaccine.2011.02.019

Table 2.

Predicted binding of the S-OIV HA peptide sequences to particular HLA-DRB1 alleles.

A/California/07/2009 HA region Peptide Epitope Sequence Predicted binding restriction to HLA-DRB1 alleles (top 5% score)
101 301 401 701 801 1101 1301 1501
36–53 VLEKNVTVTHSVNLLEDKa x X X x X X x
43–60 VTHSVNLLEDKHNGKLCK X X X X
113–132 IDYEELREQLSSVSSFERFE X X X X X X X
359–376 TGMVDGWYGYHHQNEQGS x x x x
394–411 NKVNSVIEKMNTQFTAVG X X X X x X
436–453 WTYNAELLVLLENERTLD X X X X X X X X
441–460 ELLVLLENERTLDYHDSNVK X x X X X X X
461–480 NLYEKVRSQLKNNAKEIGNG X X X X X X X X
527–549 IYQILAIYSTVASSLVLVVSLGA X X X X X X X X
530–541 ILAIYSTVASSL X X X X X
a

Whole-peptide binding predictions for HLA-DRB1 alleles are shown. Peptides are scored according to their potential to bind a particular allele. Scores in the top 5th percentile are marked with an X: a large X denotes binding of the peptide is enhanced by the core 9-mer binding peptides shown in Table 1; a small X indicates predicted binding without the contribution of a core 9-mer peptide.