Table 1.

Comparison between Carney triad GIST (case 1), pediatric (case 2) and young adult GIST (case 3)

	CT-GIST (case 1)	Pediatric GIST (case 2)	Young adult GIST (case 3)
Age at diagnosis (years)	15	13	23
Gender	female	female	female
Tumor localisation	stomach, greater curvature, antrum	stomach, lesser curvature, antrum	stomach, corpus
Growth pattern	multinodular	multinodular	multinodular
Metastases	liver (lymphangioinvasion)	liver lymph nodes	liver lymph nodes
Histomorphology	biphasic (spindled and epithelioid), hypercellular, plasmacytoid aspect	biphasic (spindled and epithelioid), hypercellular, plasmacytoid aspect	liver metastasis: hypercellular, plasmacytoid aspect lymph node metastasis: closely packed hypercellular tumor nodules with lymphangioinvasion
Immunohisto- chemistry	C-KIT/CD34 + (predominantly membranous)	C-KIT/CD34 + (predominantly membranous)	C-KIT/CD34 + (predominantly membranous)
Mutational status	WT for common C-KIT (exon 9,11,13,17) and PDGFRA (exon 12,14,18) mutations PDGFRA Exon 10 polymorphism (c. 1432 T > C; p. S478P, no alteration on protein level)	WT for common C-KIT (exon 9,11,13,17) and PDGFRA (exon 12,14,18) mutations	WT for common C-KIT (exon 9,11,13,17) and PDGFRA (exon 12,14,18) mutations
Associated diseases	paraaortal paraganglioma	?	?

CT = Carney triad, GIST = gastrointestinal stromal tumor, WT = wild type, ? = not to date