Table 5.
Significantly Altered mRNA and Proteins related to Cholesterol and Bile Acid Metabolism
| Transcriptomics | Proteomics | |||
|---|---|---|---|---|
| Cholesterol synthesis | Adj. p-value | Fold change | Adj. p-value | Fold change |
| Acetyl-Coenzyme A acetyltransferase 2 (Acat2) | 8.35E-03 | 2.1 | ||
| Farnesyl diphosphate farnesyl transferase 1 (Fdft1) | 7.22E-03 | 1.9 | ||
| Farnesyl diphosphate synthetase (Fdps) | 1.72E-02 | 1.7 | ||
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1) | 5.73E-03 | 1.6 | ||
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2) | 5.73E-03 | 1.3 | ||
| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) | 7.56E-03 | 3.0 | ||
| Isopentenyl-diphosphate delta isomerase (Idi1) | 7.22E-03 | 2.4 | 4.46E-04 | 1.7 |
| Lanosterol synthase (Lss) | 6.52E-03 | 2.8 | ||
| NAD(P) dependent steroid dehydrogenase-like (Nsdhl) | 1.38E-02 | 1.7 | ||
| Phosphomevalonate kinase (Pmvk) | 1.23E-02 | 2.2 | ||
| Sterol O-acyltransferase 2 (Soat2) | 4.33E-04 | 2.1 | ||
| SREBF chaperone (Scap) | 3.97E-03 | 1.3 | ||
| Cholesterol Transport | ||||
| ATP-binding cassette, sub-family G (WHITE), member 5 (Abcg5) | 6.99E-03 | 2.4 | ||
| ATP-binding cassette, sub-family G (WHITE), member 8 (Abcg8) | 4.61E-03 | 1.8 | ||
| ATP-binding cassette, sub-family G (WHITE), member 1 (Abcg1) | 2.88E-03 | 1.7 | ||
| Niemann Pick type C2 (Npc2) | 1.13E-02 | 1.4 | ||
| Caveolin 1, caveolae protein (Cav1) | 7.16E-03 | 4.6 | ||
| Apolipoprotein A-I (Apoa1) | 3.45E-03 | 1.2 | ||
| Chemokine (C-X-C motif) ligand 16 (Cxcl16) | 1.32E-02 | 1.4 | ||
| Scavenger receptor class B, member 1 (Scarb1) | 6.98E-03 | 1.5 | ||
| Bile Acid Synthesis | ||||
| Cytochrome P450, family 7, subfamily B, polypeptide 1 (Cyp7b1) | 3.45E-03 | -3.1 | ||
| Cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1) | 9.22E-04 | -2.2 | ||
| Cytochrome P450, family 27, subfamily A, polypeptide 1 (Cyp27a1) | 7.86E-03 | 1.4 | ||
| Cytochrome P450, family 39, subfamily a, polypeptide 1 (Cyp39a1) | 3.73E-03 | 2.1 | ||
| Alpha-methylacyl-CoA racemase (Amacr) | 2.01E-03 | -1.4 | ||
| Sterol carrier protein 2, liver (Scp2) | 1.18E-02 | -1.2 | ||
| Bile acid-CoA:amino acid N-acyltransferase (Baat) | 6.89E-04 | 1.3 | ||
| Cysteine sulfinic acid decarboxylase (Csad) | 7.17E-05 | 1.9 | ||
| Hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4) | 6.40E-04 | 1.7 | ||
| Bile Acid Transport | ||||
| Sodium/bile acid cotransporter (Slc10a1) | 7.40E-03 | 1.3 | ||
| ATP-binding cassette, sub-family B (MDR/TAP), member 11 (Abcb11) | 3.04E-03 | 1.3 | ||
| ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (Abcc3) | 2.37E-03 | 1.6 | ||
| ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (Abcc4) | 8.85E-04 | 7.0 | ||
| Organic solute transporter beta (Ostྞ) | 7.12E-03 | 1.5 | ||