Table 3. Allele and genotype association analysis for the three SNPs of LOXL1.
| SNP | XFS/XFG | Control | χ2 | p value | OR (95%CI) |
|---|---|---|---|---|---|
|
rs1048661 | |||||
|
Allele | |||||
| G |
104 (0.81) |
176 (0.69) |
6.22 |
0.013 |
1.92 (1.14–3.22) |
| T |
24 (0.19) |
78 (0.31) |
|||
|
Genotype | |||||
| GG |
42 (0.66) |
60 (0.47) |
5.78 |
0.016 |
2.13 (1.14–3.97) |
| GT |
20 (0.31) |
56 (0.44) |
|
|
|
| TT |
2 (0.03) |
11 (0.09) |
2.06 |
0.152 |
0.34 (0.07–1.58) |
| Total |
64 |
127 |
6.37 |
0.041 |
NA |
|
rs2165241 | |||||
|
Allele | |||||
| T |
72 (0.56) |
62 (0.24) |
37.89 |
0.000 |
3.98 (2.54–6.25) |
| C |
56 (0.44) |
192 (0.76) |
|||
|
Genotype | |||||
| TT |
22 (0.34) |
10 (0.08) |
21.43 |
0.000 |
6.13 (2.68–14.01) |
| CT |
28 (0.44) |
42 (0.33) |
|
|
|
| CC |
14 (0.22) |
75 (0.59) |
23.64 |
0.000 |
0.19 (0.10–0.39) |
| Total |
64 |
127 |
31.79 |
0.000 |
NA |
|
rs3825942 | |||||
|
Allele | |||||
| G |
122 (0.95) |
205 (0.81) |
14.73 |
0.000 |
4.86 (2.02–11.68) |
| A |
6 (0.05) |
49 (0.19) |
|||
|
Genotype | |||||
| GG |
58 (0.91) |
80 (0.63) |
16.21 |
0.000 |
5.68 (2.28–14.17) |
| GA |
6 (0.09) |
45 (0.35) |
|
|
|
| AA |
0 (0.00) |
2 (0.02) |
1.02 |
0.313 |
NA |
| Total | 64 | 127 | 16.33 | 0.000 | NA |
There were significant differences for the allelic proportion between the patient and control groups for all three SNPs. G allele of rs1048661, G of rs3825942, and T of rs2165241 were risk alleles for the disorder. The genotypes GG for rs1048661, GG for rs3825942, and TT for rs2165241 were risk genotypes for the disease. Total indicates the general test of association in the 2-by-3 table of disease-by-genotype. NA: not available. The asterisks indicates the OR values and p values derived from comparison of the specific genotype with all the others, i.e., GG versus GT+TT at rs1048661, TT versus CT+CT at rs2165241.