Table 4. Haplotype Association analysis between the LOXL1 SNPs and XFS/XFG.
|
Haplotype |
Proportion |
χ2 |
p value |
OR (95%CI) |
|||
|---|---|---|---|---|---|---|---|
| Case | Control | ||||||
|
rs1048661 |
rs3825942 |
|
|
|
|
|
|
| T |
G |
|
0.047 |
0.181 |
6.52 |
0.011 |
0.22 (0.06–0.77) |
| G |
G |
|
0.922 |
0.756 |
7.66 |
0.006 |
3.81(1.40–10.34) |
| G |
A |
|
0.031 |
0.063 |
0.86 |
0.353 |
0.48 (0.10–2.33) |
| Total |
|
|
|
|
7.90 |
0.019 |
NA |
|
rs1048661 |
rs2165241 |
|
|
|
|
|
|
| T |
C |
|
0.031 |
0.157 |
6.65 |
0.010 |
0.17 (0.04–0.76) |
| G |
T |
|
0.563 |
0.260 |
16.89 |
0.000 |
3.66 (1.99–6.90) |
| T |
T |
|
0.016 |
0.024 |
0.13 |
0.716 |
0.66 (0.07–6.44) |
| G |
C |
|
0.391 |
0.559 |
4.83 |
0.028 |
0.51 (0.27–0.93) |
| Total |
|
|
|
|
19.21 |
0.000 |
NA |
|
rs3825942 |
rs2165241 |
|
|
|
|
|
|
| G |
C |
|
0.406 |
0.660 |
11.35 |
0.001 |
0.35 (0.19–0.65) |
| A |
T |
|
0.016 |
0.008 |
0.25 |
0.619 |
2.00(0.12–32.51) |
| G |
T |
|
0.563 |
0.280 |
15.00 |
0.000 |
3.38 (1.80–6.34) |
| A |
C |
|
0.016 |
0.055 |
1.65 |
0.198 |
0.27 (0.03–2.26) |
| Total |
|
|
|
|
16.06 |
0.001 |
NA |
|
rs1048661 |
rs3825942 |
rs2165241 |
|
|
|
|
|
| T |
G |
C |
0.031 |
0.157 |
6.65 |
0.010 |
0.17 (0.04–0.76) |
| G |
G |
C |
0.375 |
0.504 |
2.85 |
0.092 |
0.59 (0.32–1.09) |
| G |
G |
T |
0.547 |
0.252 |
16.25 |
0.000 |
3.58 (1.90–6.76) |
| T |
G |
T |
0.016 |
0.024 |
0.13 |
0.716 |
0.66 (0.07–6.44) |
| G |
A |
C |
0.016 |
0.055 |
1.65 |
0.198 |
0.27 (0.03–2.26) |
| G |
A |
T |
0.016 |
0.008 |
0.25 |
0.619 |
2.00(0.12–32.51) |
| Total | 19.93 | 0.001 | NA | ||||
The haplotypes G-G for the SNPs rs1048661 and rs3825942, G-T for the SNPs rs1048661 and rs2165241, and G-T for the SNPs rs3825942 and rs2165241 were identified to be significantly associated with XFS/G. The haplotype G-G-T for the three SNPs was identified to be significantly associated with XFS/G. Total indicates omnibus tests, while the others indicate the haplotype-specific tests. The OR values were obtained from comparison of each individual haplotype with all the other haplotypes, i.e., T-G versus G-G + G-A for the SNPs rs1048661 and rs3825942, etc. NA: not available.