Table 5. Allele and genotype association analysis between the LOXL1 SNPs and different gender of XFS/XFG.
|
|
|
|
Genotype count (proportion) |
Allele count (proportion) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gender | Group | rs1048661 (n) | TT | GT | GG | χ2 | p value | G | T | χ2 | p value | OR (95%CI) |
| Male |
XFS/XFG |
41 |
1 (0.02) |
14 (0.34) |
26 (0.63) |
4.08 |
0.130 |
66 (0.80) |
16 (0.20) |
3.92 |
0.048 |
1.90 (1.00–3.59) |
| |
Control |
81 |
10 (0.12) |
31 (0.38) |
40 (0.49) |
|
|
111 (0.69) |
51 (0.31) |
|
|
|
| Female |
XFS/XFG |
23 |
1 (0.04) |
6 (0.26) |
16 (0.70) |
4.98 |
0.083 |
38 (0.83) |
8 (0.17) |
2.32 |
0.128 |
1.97 (0.82–4.78) |
| |
Control |
46 |
1 (0.02) |
25 (0.54) |
20 (0.43) |
|
|
65 (0.71) |
27 (0.29) |
|
|
|
|
|
|
|
Genotype count (proportion) |
Allele count (proportion) |
||||||||
|
Gender |
Group |
rs2165241 (n) |
CC |
CT |
TT |
χ2 |
p value |
T |
C |
χ2 |
p value |
OR (95%CI) |
| Male |
XFS/XFG |
41 |
12 (0.29) |
19 (0.46) |
10 (0.24) |
9.45 |
0.009 |
39 (0.48) |
43 (0.52) |
10.8 |
0.001 |
2.51 (1.44–4.39) |
| |
Control |
81 |
46 (0.57) |
27 (0.33) |
8 (0.10) |
|
|
43 (0.27) |
119 (0.73) |
|
|
|
| Female |
XFS/XFG |
23 |
2 (0.09) |
9 (0.39) |
12 (0.52) |
27.6 |
0.000 |
33 (0.72) |
13 (0.28) |
34.1 |
0.000 |
9.75 (4.31–22.07) |
| |
Control |
46 |
29 (0.63) |
15 (0.33) |
2 (0.04) |
|
|
19 (0.21) |
73 (0.79) |
|
|
|
|
|
|
|
Genotype count (proportion) |
Allele count (proportion) |
||||||||
|
Gender |
Group |
rs3825942 (n) |
GG |
GA |
AA |
χ2 |
p value |
G |
A |
χ2 |
p value |
OR (95%CI) |
| Male |
XFS/XFG |
41 |
36 (0.88) |
5 (0.12) |
0 (0.00) |
8.41 |
0.015 |
77 (0.94) |
5 (0.06) |
7.89 |
0.005 |
3.79 (1.42–10.14) |
| |
Control |
81 |
51 (0.63) |
28 (0.35) |
2 (0.02) |
|
|
130 (0.80) |
32 (0.20) |
|
|
|
| Female |
XFS/XFG |
23 |
22 (0.96) |
1 (0.04) |
0 (0.00) |
8.46 |
0.004 |
45 (0.98) |
1 (0.02) |
7.19 |
0.007 |
10.2 (1.31–79.26) |
| Control | 46 | 29 (0.63) | 17 (0.37) | 0 (0.00) | 75 (0.82) | 17 (0.18) | ||||||
There were significant differences in allelic and genotypic proportion between the genders in the patient and control groups for the SNPs rs2165241 and rs3825942. T allele of rs2165241 and G of rs3825942 were risk alleles for the disorder for both the male and female groups. Total indicates the general test of association in the 2-by-3 table of disease-by-genotype.