Table 6. Allele and genotype association analysis between the LOXL1 SNPs and different aged XFS/XFG.
|
|
|
|
Genotype count (proportion) |
Allele count (proportion) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Years | Group | rs1048661 (n) | TT | GT | GG | χ2 | p value | G | T | χ2 | p value | OR (95%CI) |
| ≤65 |
XFS/XFG |
20 |
0 (0.00) |
4 (0.20) |
16 (0.80) |
7.32 |
0.026 |
36 (0.90) |
4 (0.10) |
6.48 |
0.011 |
3.86 (1.29–11.58) |
| |
Control |
65 |
4 (0.06) |
31(0.48) |
30 (0.46) |
|
|
91 (0.70) |
39 (0.30) |
|
|
|
| >65 |
XFS/XFG |
44 |
2 (0.05) |
16(0.36) |
26 (0.59) |
2.04 |
0.360 |
68 (0.77) |
20 (0.23) |
1.95 |
0.163 |
1.56 (0.83–2.92) |
| |
Control |
62 |
7 (0.11) |
25 (0.40) |
30 (0.48) |
|
|
85 (0.69) |
39 (0.31) |
|
|
|
|
|
|
|
Genotype count (proportion) |
Allele count (proportion) |
||||||||
|
Years |
Group |
rs2165241 (n) |
CC |
CT |
TT |
χ2 |
p value |
T |
C |
χ2 |
p value |
OR (95%CI) |
| ≤65 |
XFS/XFG |
20 |
2 (0.10) |
12 (0.60) |
6 (0.30) |
16.3 |
0.000 |
24 (0.60) |
16 (0.40) |
16.5 |
0.000 |
4.41 (2.09–9.30) |
| |
Control |
65 |
40 (0.62) |
17 (0.26) |
8 (0.12) |
|
|
33 (0.25) |
97 (0.75) |
|
|
|
| >65 |
XFS/XFG |
44 |
12 (0.27) |
16 (0.36) |
16 (0.36) |
21.7 |
0.000 |
48 (0.55) |
40 (0.45) |
21.6 |
0.000 |
3.93 (2.18–7.10) |
| |
Control |
62 |
35 (0.56) |
25 (0.40) |
2 (0.03) |
|
|
29 (0.23) |
95 (0.77) |
|
|
|
|
|
|
|
Genotype count (proportion) |
Allele count (proportion) |
||||||||
|
Years |
Group |
rs3825942 (n) |
GG |
GA |
AA |
χ2 |
p value |
G |
A |
χ2 |
p value |
OR (95%CI) |
| ≤65 |
XFS/XFG |
20 |
17 (0.85) |
3 (0.15) |
0 (0.00) |
1.61 |
0.204 |
37 (0.93) |
3 (0.07) |
1.38 |
0.241 |
2.11 (0.59–7.54) |
| |
Control |
65 |
46 (0.71) |
19 (0.29) |
0 (0.00) |
|
|
111 (0.85) |
19 (0.15) |
|
|
|
| >65 |
XFS/XFG |
44 |
41 (0.93) |
3 (0.07) |
0 (0.00) |
18.4 |
0.000 |
85 (0.97) |
3 (0.03) |
16.9 |
0.000 |
9.04 (2.66–30.71) |
| Control | 62 | 34 (0.55) | 26 (0.42) | 2 (0.03) | 94 (0.76) | 30 (0.24) | ||||||
There were significant differences of the allelic and genotypic proportion in different aged patient and control groups for all three SNPs. G allele of rs1048661 was a risk allele for the disorder in the below 65-year-old group. T of rs2165241 was a risk allele for the disorder in both aged groups. G of rs3825942 was a risk allele for the disorder in the over 65-year-old group. The genotypes also showed significant differences in the below 65-year-old group of rs1048661, both aged groups of rs2165241, and over 65-year-old group of rs3825942. Total indicates the general test of association in the 2-by-3 table of disease-by-genotype.