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. 2011 Jul 6;6(7):e21917. doi: 10.1371/journal.pone.0021917

Figure 4. JWH-018 and M1 decreased mouse locomotor activity in a CB1R-dependent manner, similar to Δ9-THC.

Figure 4

A. Intraperitoneal (i.p.) administration of 3 mg/kg JWH-018, 10 mg/kg JWH-018 M1, and 30 mg/kg Δ9-THC decreased locomotor activity relative to vehicle controls over a 10 h time course, beginning 60 min after injection. B. Area under the curve data generated from the 10 h time-course shows 3 mg/kg JWH-018, 10 mg/kg JWH-018 M1, and 30 mg/kg Δ9-THC significantly decrease locomotor activity relative to vehicle controls (*P<0.05 vs. vehicle controls, Kruskal-Wallis one-way ANOVA with Tukey HSD test, n = 5). Co-administration of each cannabinoid with the CB1R-preferring antagonist/inverse agonist AM251 (10 mg/kg) restored locomotor activity to vehicle control levels.