Table 3.
Association results from previously published studies of RNASEL variants and sporadic and familial prostate cancer
| RNASEL rs# | Author (Year) | Reference number | Family history subgroup* | OR (95% CI) |
|---|---|---|---|---|
| rs12723593 | Fesinmeyer et al. (2011) | all | 1.13 (1.00 – 1.27) | |
| rs635261 | Fesinmeyer et al. (2011) | all | 0.92 (0.82 – 1.03) | |
| Meyer et al. (2010) | 25 | all | 0.90 (0.71 – 1.13) | |
| rs12729828 | Fesinmeyer et al. (2011) | all | 1.07 (0.89 – 1.27) | |
| Meyer et al. (2010) | 25 | all | 1.09 (0.90 – 1.33) | |
| rs627839 | Fesinmeyer et al. (2011) | all | 1.16 (0.98 – 1.39) | |
| rs11087829 | Fesinmeyer et al. (2011) | all | 0.90 (0.77 – 1.05) | |
| Meyer et al. (2010) | 25 | all | 0.90 (0.69 – 1.17) | |
| rs627928 (Asp541Glu) | Fesinmeyer et al. (2011) | all | 1.17 (0.97 – 1.40) | |
| Maier et al. (2005) | 11 | all | 0.83† (0.51 – 1.37) | |
| Meyer et al. (2010) | 25 | all | 0.97† (0.78 – 1.22) | |
| Wiklund et al. (2004) | 8 | sporadic only | 0.77 (0.59 – 1.00) | |
| Rokman et al. (2002) | 10 | sporadic only | NA (no association) | |
| Rokman et al. (2002) | 10 | familial only | NA (no association) | |
| Nakazato et al. (2003) | 30 | familial only, Japanese cases | 6.94 (3.98 – 12.10) | |
| Breyer et al. (2009) | 22 | familial only | 0.64 (p = 0.018) | |
| rs486907 (Arg462Gln) | Fesinmeyer et al. (2011) | all | 0.88 (0.75 – 1.04) | |
| Fesinmeyer et al. (2011) | all Gleason ≥ 7 | 0.72 (0.53 – 0.98) | ||
| Maier et al. (2005) | 11 | all | 0.88 (0.53 – 1.44) | |
| Shook et al. (2007) | 24 | all | 1.04 (0.80 – 1.36) | |
| Meyer et al. (2010) | 25 | all | 0.96 (0.75 – 1.24) | |
| Wang et al. (2002) | 9 | sporadic only | p = 0.92 (OR NA) | |
| Rennert et al. (2005) | 21 | sporadic only | 1.40 (0.99 – 1.90) | |
| Rennert et al. (2005) | 21 | sporadic only Gleason < 7 | 1.50 (1.04 – 2.20) | |
| Rokman et al. (2002) | 10 | sporadic only | 1.12 (0.60 – 2.07) | |
| Casey et al. (2002) | 23 | familial only | 1.51 (1.12 – 2.05) | |
| Wang et al. (2002) | 9 | familial only | 0.55 (0.33 – 0.93) | |
| Breyer et al. (2009) | 22 | familial only | 1.34 (1.03 – 1.76) | |
| Breyer et al. (2009) | 22 | familial only Gleason ≥ 7 | 1.26 (0.85 – 1.88) | |
| Rennert et al. (2005) | 21 | familial only | 0.48 (0.24 – 0.95) | |
| Rennert et al. (2005) | 21 | familial only Gleason <7 | 0.43 (0.21 – 0.88) | |
| Rokman et al. (2002) | 10 | familial only | 1.96 (0.95 – 4.03) | |
| rs56250729 (Ile97Leu) | Fesinmeyer et al. (2011) | all | 1.88 (1.05 – 3.34) | |
| Maier et al. (2005) | 11 | all | 2.32 (0.49 – 11.0) | |
| Wang et al. (2002) | 9 | familial only | p = 0.23 (OR NA) | |
| Gly59Ser | Fesinmeyer et al. (2011) | all | 0.57 (0.27 – 1.20) | |
| Rokman et al. (2002) | 10 | sporadic only | NA (no association) | |
| rs682585 | Fesinmeyer et al. (2011) | all | 1.07 (0.91 – 1.26) | |
| Meyer et al. (2010) | 25 | all | 0.91 (0.73– 1.15) |
OR: Odds Ratio; CI: Confidence Interval; NA: not available (estimates not provided in manuscript text).
*
Family history subgroups defined as follows: sporadic only = cases with no family history of prostate cancer; familial only = cases with some family history of prostate cancer; all = cases not selected on basis of family history.
†
inverse of published OR and 95% CI for opposite allele.