Table 2. Serum concentrations (geometric mean and 95% confidence intervals*) of sex steroid hormones and sex hormone binding globulin by age, 1,351 male participants, NHANES III, 1988-1991.
| Age group (years) | Number of years of age corresponding to a 2% change in geometric mean hormone concentration** | |||||||
|---|---|---|---|---|---|---|---|---|
| 20-29 | 30-39 | 40-49 | 50-59 | 60-69 | 70+ | All men | Excluding men with prevalent disease at recruitment | |
| Total testosterone (nmol/L) | 20.68 (19.54-21.93) |
18.77 (17.97-19.61) |
16.66 (15.20-18.25) |
15.89 (14.85-17.00) |
15.62 (14.71-16.55) |
12.28 (10.38-14.57) |
2.4 | 2.7 |
| Free testosterone (nmol/L) | 0.458 (0.433-0.456) |
0.402 (0.385-0.420) |
0.326 (0.295-0.357) |
0.298 (0.274-0.323) |
0.264 (0.246-0.281) |
0.180 (0.146-0.219) |
1.3 | 1.4 |
| Total estradiol (pmol/L) | 142.54 (138.07-147.17) |
133.29 (127.38-139.46) |
124.56 (117.40-132.16) |
128.19 (120.96-135.90 |
125.11 (116.81-133.99) |
120.89 (111.52-130.98) | 8.1 | 7.6 |
| Free estradiol (pmol/L) | 3.74 (3.60-3.89) |
3.49 (3.30-3.67) |
3.16 (2.97-3.38) |
3.27 (3.08-3.49) |
3.01 (2.83-3.19) |
2.75 (2.50-3.05) |
4.1 | 4.1 |
| Androstanediol glucuronide (nmol/L) | 31.7966 (30.11-33.59) |
25.03182 (23.11-27.12) |
24.541 (22.34-26.95) |
22.64174 (19.42-26.38) |
20.01692 (17.16-23.35) |
18.84322 (16.86-21.06) |
-1.6 | -1.7 |
| SHBG (nmol/L) | 29.01 (26.58-31.66) |
30.87 (29.04-32.83) |
35.68 (33.14-38.42) |
38.31† (35.16-41.74) |
45.21 (41.82-48.87) |
56.21 (52.81-59.83) |
1.6 | 1.6 |
| Molar ratio of estradiol (nmol/L) to testosterone (nmol/L) | 6.88 (6.47-7.31) |
7.1 (6.73-7.48) |
7.47 (6.65-8.39) |
8.07 (7.50-8.68) |
8.01 (7.53-8.52) |
9.82 (8.81-10.96) |
-3.4 | -4.0 |
*
Adjusted for race/ethnicity, percent body fat, physical activity, smoking, and alcohol consumption
**
Based on white non-smoking men in the second category of drinking and exercise with 24.9% body fat