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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2011 Feb 17;22(4):351–358. doi: 10.1016/j.semcdb.2011.02.017

Figure 5. Antisense non-coding RNA mediated concordant regulation of Nanog.

Figure 5

(A) The antisense non-coding RNA expressed from the Nanog psuedogene is able to interact with various protein complexes. (B) Suppression of PurA or Nucleolin (NCL) results in a loss of one protein complex involved in regulating or trafficking the particular antisense non-coding RNA resulting in (C) the enhanced targeting of the antisense non-coding RNA and an epigenetic silencing complex to the homology containing loci in the coding region of Nanog. (D) The result of enhanced epigenetic targeting of the coding region in Nanog is increased mRNA and protein expression.