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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Jun 19;18(7):846–853. doi: 10.1038/nsmb.2068

Figure 5.

Figure 5

Redesign of RGS18 gain-of-function mutants. (a) Sequences of RGS16, RGS18 and its mutants, color-coded as in Figure 4a. (b) Positions of the three RGS18 sites that were mutated in the redesign experiments, visualized as in Figure 4b. Corresponding RGS18 residue numbers are in parentheses. (c) GAP activities of the redesigned RGS18 mutants compared to activities of wild-type proteins. kgap values were determined as in Figure 4c.