Table 1.
Lipids by APOE Genotype
| Genotype | Total Cholesterol (mmol/L) |
LDLc (mmol/L) |
HDLc (mmol/L) |
Triglyceridea (mmol/L) |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean (SD) | Coeffb | 95% CI | pc | Mean (SD) | Coeffb | 95% CI | pc | Mean (SD) | Coeffb | 95% CI | pc | Geometric Mean | (IQR) | Coeffb | 95% CI | pc | |
| ε2/ε2 | 26 | 3.61 (.65) | −.64 | (−.89, −.40) | 1.37 (.66) | −.96 | (−1.17, −.75) | 1.55 (.44) | .15 | (.03, .27) | 1.35 | (.95, 1.86) | 1.34 | (1.14, 1.58) | ||||
| ε2/ε3 | 382 | 3.95 (.58) | −.29 | (−.36, −.22) | 1.95 (.48) | −.38 | (−.44, −.32) | 1.48 (.33) | .08 | (.04, .11) | 1.04 | (.79, 1.34) | 1.04 | (.99, 1.09) | ||||
| ε4/ε2 | 74 | 4.17 (.65) | −.07 | (−.22, .07) | 2.14 (.54) | −.2 | (−.33, −.07) | 1.45 (.36) | .05 | (−.02, .12) | 1.14 | (.86, 1.53) | 1.14 | (1.03, 1.26) | ||||
| ε3/ε3 | 1626 | 4.25 (.65) | 0 | — | 2.34 (.57) | 0 | — | 1.40 (.30) | 0 | — | 1 | (.75, 1.33) | 1 | — | ||||
| ε3/ε4 | 709 | 4.39 (.62) | .14 | (.09, .20) | 2.51 (.56) | .16 | (.12, .21) | 1.35 (.29) | −.05 | (−.08, −.03) | 1.07 | (.78, 1.42) | 1.07 | (1.04, 1.11) | ||||
| ε4/ε4 | 58 | 4.65 (.57) | .4 | (.23, .56) | <.0001 | 2.72 (.53) | .37 | (.23, .52) | <.0001 | 1.31 (.22) | −.09 | (−.17, −.01) | <.0001 | 1.26 | (1.00, 1.60) | 1.25 | (1.12, 1.40) | <.0001 |
APOE, apolipoprotein E; LDLc, low-density lipoprotein cholesterol; HDLc, high-density lipoprotein cholesterol; CI, confidence interval; IQR, interquartile range.
a
Coefficient represents the ratio of geometric means, because triglyceride data are log-transformed.
b
Coefficient from linear regression adjusted for age and gender with ε3/ε3 genotype as reference group.
c
The p value for heterogeneity from analysis of covariance model.