Table 3.
Associations of APOE Genotype with IQ, WORD, and WOLD Tests
| Coeffa | 95% CI | pb | |
|---|---|---|---|
| Total IQc, n = 3925 | |||
| ε2/ε2 | 3.62 | (−2.20, 9.44) | |
| ε2/ε3 | .29 | (−1.24, 1.83) | |
| ε2/ε4 | .85 | (−2.34, 4.04) | |
| ε3/ε3 | — | — | |
| ε3/ε4 | .13 | (−1.10, 1.35) | |
| ε4/ε4 | 2.61 | (−.87, 6.09) | .58 |
| Verbal IQc, n = 3938 | |||
| ε2/ε2 | 3.86 | (−2.04, 9.77) | |
| ε2/ε3 | −.07 | (−1.63, 1.48) | |
| ε2/ε4 | .30 | (−2.94, 3.53) | |
| ε3/ε3 | — | — | |
| ε3/ε4 | −.37 | (−1.61, .88) | |
| ε4/ε4 | 2.24 | (−1.29, 5.77) | .58 |
| Performance IQc, n = 3940 | |||
| ε2/ε2 | 2.78 | (−3.29, 8.85) | |
| ε2/ε3 | .83 | (−.76, 2.43) | |
| ε2/ε4 | 1.27 | (−2.06, 4.60) | |
| ε3/ε3 | — | — | |
| ε3/ε4 | .93 | (−.35, 2.21) | |
| ε4/ε4 | 2.41 | (−1.22, 6.04) | .46 |
| WORDd, n = 4391 | |||
| ε2/ε2 | 1.46 | (−1.59, 4.50) | |
| ε2/ε3 | −.31 | (−1.15, .52) | |
| ε2/ε4 | −.44 | (−2.21, 1.33) | |
| ε3/ε3 | — | — | |
| ε3/ε4 | −.27 | (−.94, .40) | |
| ε4/ε4 | 1.02 | (−.92, 2.96) | .64 |
| WOLDd, n = 3940 | |||
| ε2/ε2 | .36 | (−.35, 1.06) | |
| ε2/ε3 | −.03 | (−.21, .15) | |
| ε2/ε4 | .08 | (−.29, .46) | |
| ε3/ε3 | — | — | |
| ε3/ε4 | −.06 | (−.21, .09) | |
| ε4/ε4 | .28 | (−.14, .69) | .56 |
APOE, apolipoprotein E; WORD, Wechsler Objective Reading Dimensions; WOLD, Wechsler Objective Language Dimensions; CI, confidence interval.
a
From linear regression adjusted for gender and the age of child in months.
b
The p values for heterogeneity from analysis of covariance model.
c
Coefficients represent change in IQ score in IQ points.
d
Coefficients represent point changes in WORD and WOLD scores.