Schematic diagram of the likely intracellular signalling pathways at play in controlling contractility of prostatic smooth muscle cells. ACh, acetylcholine; Adr, adrenaline; AMP, adenosine monophosphate; ATP, adenosine 5′-triphosphate; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; DAG, diacylglycerol; GMP, guanosine monophosphate; GPCR, G-protein coupled receptor; IP3, inositol triphosphate; MLC, myosin light chain; NO, nitric oxide; PDE, phosphodiesterase; PIP2, phosphatidylinositol bisphosphate; PK, protein kinase; PL, phospholipase.