Figure 1.

Locomotor activity. (A) effect of the GABA_B receptor agonist CGP44532 and the positive modulator GS39783 on the locomotor activity in mice habituated to activity cages. Compounds were given i.p. in doses of 0.250 mg·kg⁻¹ (CGP44532) and 30 mg·kg⁻¹ (GS39783) after 30 min of the habituation period. Locomotor activity was monitored over 100 min after drug administration. (B) spontaneous locomotor activity after i.p. administration of the GABA_B receptor agonist CGP44532 and the positive allosteric modulator, GS39783. Values represent the mean ± SEM ambulation scores during 100 min. CGP44532 was administered 120, 60 and 30 min before measurements and GS39783 was administered 30 min before the test, *P < 0.05.