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. 2011 Jul;163(5):1078–1085. doi: 10.1111/j.1476-5381.2011.01308.x

Figure 7.

Figure 7

Anti-hypertensive effects of AVE3085 in SHR. In (A) oral administration of AVE3085 for 4 weeks reduced systolic blood pressure in SHR but had no effects on systolic blood pressure in WKY rats. In panel (B), male eNOS−/− mice (4 months old) had a significantly higher systolic blood pressure than the wild-type C57BL/6J mice, but treatment of eNOS−/− mice with AVE3085 for up to 8 weeks had no effect on blood pressure. Data are mean ± SEM of five to seven animals. WT: wild-type mice, AVE(+): with AVE3085 treatment, AVE(–): without AVE3085 treatment. ##P < 0.001 versus WKY control, **P < 0.001 versus control, *P < 0.05 versus WT.