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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: Neuropharmacology. 2008 Oct 17;56(2):507–513. doi: 10.1016/j.neuropharm.2008.10.005

Figure 2.

Figure 2

Time course effect of the intra-mPFC administration of the 5-HT2CR agonist Ro 60-0175 and the 5-HT2CR antagonist SB 242084 on the increase in accumbal DA outflow induced by cocaine. Ro 60-0175 (Ro; left panels) and SB 242084 (SB; right panels) were injected into the mPFC (vertical arrows) 15 min before cocaine. The doses injected are indicated in parentheses in µg/ 0.2 µl. Cocaine (coc) was administered intraperitoneally at 10 mg/kg at time zero. Data are presented as the mean ± SEM percentages of the baseline calculated from the three samples preceding the first drug administration (n= 6–10 animals/group). ***p<0.001 versus the vehicle/vehicle (v / v) group and ++p<0.01 versus the vehicle/cocaine (v / coc) group (Fisher's PLSD test).

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