Table 2.

Univariate analysis of clinicopathologic characteristics associated with overall survival in recurrent melanoma patients (n = 114)

Variable	n = 114a	Median survival (years)	p valueb
Stage at initial diagnosis			<0.001
I	31 (27%)	9.7
II	34 (30%)	7.1
III	42 (37%)	2.7
IV	7 (6%)	0.7
Disease-free survival (years)			<0.001
<1	48 (42%)	2.5
1–3	36 (32%)	4.8
>3	30 (26%)	10.8
Stage at first recurrence			0.001
III	80 (70%)	7.9
IV	34 (30%)	2.9
Total number of recurrences			<0.001
1	25 (22%)	NAc
2	19 (17%)	9.5
≥3	70 (61%)	3.0
LDH level at first recurrence			0.03
Normal	50 (82%)	6.9
High	11 (18%)	1.5
ECOG performance status at first recurrence			<0.001
0	49 (82%)	10.2
1 or 2	11 (18%)	1.7
Ki-67 expression level in recurrent tissue			0.03
Low (≤25%)	57 (50%)	9.5
High (>25%)	57 (50%)	3.6

^aNumber of patients may not sum to 114 due to unavailable data (unknown values).

^bBy logrank test.

^cInsufficient deaths to determine median survival.