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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: Hypertension. 2010 Oct 11;56(5):956–963. doi: 10.1161/HYPERTENSIONAHA.110.155101

Figure 2.

Figure 2

Hyperosmotic stimulation induces MIF mRNA expression in the PVN via an AT1R-dependent process. Rats were injected ICV with either 2 μL of losartan (Los; 2.1 nmol/μL) or 2 μL of isoosmotic (0.9%) saline. Fifteen minutes later, half of the rats from each group were injected ICV with 2 μL of isoosmotic (0.9%) saline, and the others were injected ICV with 2 μL of 2.0-mol/L NaCl. Three hours later brains were removed for analysis of MIF mRNA in the PVN. Data are mean±SEM of MIF mRNA levels normalized against 18S rRNA (n=5 to 10 per treatment condition). *P<0.05 (Student t test).