Table 1. Inhibition of telomerase by 2′-MOE RNA and 2′-MOE RNA/DNA chimeric oligomers.

Compound	Chemistry	No.	Sequence	IC50 (µM)
				25°C	37°C
			3′-GAAGAGUCAAUCCCAAUCUG-5′ (RNA template)
ISIS24690	2′-MOE RNA	I	CAGUUAGGGUUAG	0.03	0.01
ISIS125626	2′-MOE RNA	II	CAGUUAGAAUUAG (mismatch)	>10	>10
ISIS125625	2′-MOE RNA	III	CAGUUAGGGUUAG	0.002	0.009
ISIS125627	2′-MOE RNA	IV	CAGUUAGAAUUAG (mismatch)	3.3	7
ISIS24691	2′-MOE RNA	V	CAGUUAGGGUUAG	0.003	0.007
ISIS125628	2′-MOE RNA	VI	CAGUUAGAAUUAG (mismatch)	0.7	1.1
ISIS113753	2′-MOE RNA/DNA	VII	CUUCUCAGTTAGGGTUAGAC	0.025	0.02
ISIS113754	2′-MOE RNA/DNA	VIII	CUUCUCAGTTAGAATUAUAC (mismatch)	1.0	>5.5
ISIS113751	2′-MOE RNA/DNA	IX	CUUCUCAGTTAGGGTUAGAC	0.002	0.005
ISIS113752	2′-MOE RNA/DNA	X	CUUCUCAGTTAGAATUAUAC (mismatch)	0.004	0.010
ISIS113749	2′-MOE RNA/DNA	XI	CUUCUCAGTTAGGGTUAGAC	0.006	0.009
ISIS113750	2′-MOE RNA/DNA	XII	CUUCUCAGTTAGAATUAUAC (mismatch)	0.008	0.009

Underlined nucleotides have PS linkages. The italicized bases in the 2′-MOE/DNA chimera are DNA.