Table 2. Inhibition of intracellular telomerase by 2′-MOE RNA and 2′-MOE RNA/DNA chimeric oligomers 1, 4 and 7 days after transfection.

Compound	Chemistry	No.	Sequence	Conc.	Inhibition (%)
					Day 1	Day 4	Day 7
			3′-GAGUCAAUCCCAAUCUG-5′ (RNA template)
ISIS125625	2′-MOE RNA	III	CAGUUAGGGUUAG	500	82	67	76
				100	77	87	76
ISIS125627	2′-MOE RNA	IV	CAGUUAGAAUUAG (mismatch)	500	24	nd	nd
				100	23	20	nd
ISIS24691	2′-MOE RNA	V	CAGUUAGGGUUAG	500	68	87	50
				100	80	78	52
ISIS125628	2′-MOE RNA	VI	CAGUUAGAAUUAG (mismatch)	500	30	nd	nd
				100	32	nd	nd
ISIS113749	2′-MOE RNA/DNA	XI	CUUCUCAGTTAGGGTUAGAC	500	54	93 70
				100	68	91	60
ISIS113750	2′-MOE RNA/DNA	XII	CUUCUCAGTTAGAATUAUAC (mismatch)	500	66	65	nd
				100	18	42	nd

Underlined nucleotides have PS linkages. The italicized bases in the 2′-MOE/DNA chimera are DNA. Bases that are mismatched relative to the RNA template of hTR are in bold. Nd, no significant inhibition detected. Individual experiments were performed in duplicate and all experiments were repeated at least once. Reported values are an average of the percent inhibition values for all determinations.