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In vivo effect of isocyanate exposure on chitinases. Chitinase-1 enzyme activity levels (panel A) and chitinase 3-like-1 protein levels (panel B) in study subjects’ serum were measured pre- and (24 hrs) post- respiratory tract exposure. Each line represents measurements from a single individual, with at least one active (+) chitinase allele (N=6), or two copies (−/−) of the non-active (polymorphic) allele (N=4, the only 4 subjects in our study population with this genotype.)
