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. 2011 May 6;20(15):3042–3051. doi: 10.1093/hmg/ddr208

Table 1.

In silico analysis of six missense mutations of the NLGN2 gene identified in this study

Mutation in cDNA	Amino acid change	Predicted deleterious
		PolyPhen-2^a	SIFT^b
c.644G > A	R215H	Probably damaging	Affect protein function
c.1528G > A	V510M	Benign	Tolerated
c.1862G > A	R621H	Possibly damaging	Affect protein function
c.1909G > A	A637T	Benign	Tolerated
c.2399C > T	P800L	Benign	Tolerated
c.2455C > T	A819S	Benign	Tolerated

^aPolyPhen-2: http://genetics.bwh.harvard.edu/pph2/

^bSIFT: http://sift.jcvi.org/