Table 4.

Main findings for parasite-induced genetically driven autoimmune Chagas' disease

Feature of kDNA-mutated T cells	Clonala proliferation	Enhanced capacity	Pathologyb
Genetically modified T cell clonesc	Yes	Attack of target cells	Severe lymphocyte infiltrates in the lesions
Accelerated rejection of target cells	Yes	Rejection of heart cells and neurons	Lysis of target cells
Preformed capacity to lyse target cells	Yes	Production of clinical manifestations	Cardiomegaly and megasyndromes

^aEach T cell performing target cell lysis is a cytotoxic T lymphocyte clone.

^bParasite-free pathological lesions in the chicken model.

^cRupture of ORFs encoding cell growth and differentiation, immune factors, and others genes.