Table 2.
Coagulation studies
| Setting | Material | Factor | Change in concn | Reference |
|---|---|---|---|---|
| Human studies | ||||
| Thirty-eight patients with bacterial meningitis (GCSa of <9 vs GCS of >9) | Serum | PLT/dPLT | ↑ | 264 |
| PTr | ↓ | |||
| INR | ↑ | |||
| D dimers | ↑ | |||
| Ninety-two patients with bacterial meningitis vs controls and patients with viral meningitis | CSF | sTF | ↑ | 525 |
| TaT | ↑ | |||
| pT fragment F1+2 | ↑ | |||
| tPA | ↑ | |||
| PAI-1 | ↑ | |||
| D dimers | ↑ | |||
| Twelve patients with bacterial meningitis vs 10 patients with group B streptococcus and 10 controls | Serum/CSF | uPA | ↑/↑ | 536 |
| uPAR | =/↑ | |||
| PAI-1 | =/↑ | |||
| PA-dependent platelet activation | ↑ | |||
| Twelve patients with bacterial meningitis vs 10 patients with group B streptococcus and 10 controls | Serum/CSF | tPA | ↑↑/↑ | 535 |
| Murine studies | ||||
| C57BL/6 mice | Brain | tPA/uPA | ↑/= | 379 |
| tPA−/− mice | Frozen samples | PAI-1/2 | ↑/↑ | |
| uPAR−/− mice | Sections | uPAR | ↑ | |
| MIP-2 | ↑ | |||
| KC | ↑ | |||
| Albumin | ↑ |
a
GCS, Glasgow coma score.