Table 1.
Average fold change in release of cytokines from glia in response to CGRP (500 nM) for 8 or 24 h when compared to unstimulated control levels. CGRP stimulation caused a >3-fold increase in all the cytokines over control (p < 0.05). Grey boxes indicate cytokines thought to have an anti-inflammatory role.
| RayBio rat cytokine antibody array |
8 h | 24 h | ||
|---|---|---|---|---|
| Fold change | ±SEM | Fold change | ±SEM | |
| CINC-3 | 40.77 | 8.82 | 25.29 | 2.60 |
| Fractalkine | 77.11 | 5.11 | 15.74 | 2.47 |
| GM-CSF | 30.51 | 2.87 | 5.17 | 0.10 |
| IL-1α | 32.08 | 9.50 | 12.47 | 1.71 |
| Leptin | 8.5 | 2.28 | 4.69 | 0.48 |
| MIP-3a | 9.58 | 0.77 | 3.99 | 0.88 |
| TIMP-1 | 13.56 | 0.77 | 10.79 | 2.49 |
| β-NGF | 7.67 | 0.31 | 21.49 | 2.62 |
| CNTF | 9.08 | 0.34 | 26.51 | 0.35 |
| IL-1β | 12.78 | 0.27 | 17.22 | 0.14 |
| IL-6 | 10.67 | 0.47 | 22.77 | 0.98 |
| LIX | 7.49 | 0.45 | 22.88 | 0.83 |
| TNF-α | 10.47 | 0.06 | 16.74 | 0.88 |
| VEGF | 6.72 | 0.23 | 33.66 | 4.08 |
| IL-10 | 10.04 | 0.33 | 26.91 | 0.72 |
| IL-4 | 15.45 | 0.60 | 22.68 | 0.07 |
| CINC-2 | 15.28 | 1.99 | 15.88 | 1.31 |
| IFN-γ | 20.92 | 2.21 | 19.67 | 1.31 |
| MCP-1 | 8.33 | 0.12 | 8.02 | 0.12 |