Table 3.
Ingestive and exploratory behaviors following administration of selective monoamine antagonists into vmPFC
| Food intake (g) | Mean eat bout duration (s) | Water intake (ml) | Mean drink bout duration (s) | Locomotor counts | Rearing counts | |
|---|---|---|---|---|---|---|
| Muscimol-induced inactivation | ||||||
| 0 | 5.2 ± 0.38 | 25.53 ± 1.98 | 4.1 ± 0.55 | 18.46 ± 3.97 | 51.57 ± 5.35 | 64.57 ± 8.96 |
| 75 | 5.3 ± 0.25 | 52.69 ± 3.79** | 5.1 ± 0.57 | 16.12 ± 1.33 | 38.86 ± 5.93* | 42.57 |
| SCH23390 | ||||||
| 0 | 6.1 ± 0.64 | 60.4 ± 10.56 | 4.9 ± 0.61 | 27.2 ± 4.68 | 24.4 ± 3.93 | 51.0 ± 8.09 |
| 1 | 6.8 ± 0.51 | 58.8 ± 9.68 | 4.4 ± 0.85 | 25.6 ± 5.11 | 17.5 ± 2.73 | 36.6 ± 6.02 |
| 2 | 5.4 ± 0.58 | 64.1 ± 9.52 | 4.7 ± 0.60 | 24.6 ± 3.19 | 18.9 ± 2.42 | 37.8 ± 4.44 |
| Raclopride | ||||||
| 0 | 4.4 ± 0.48 | 48.3 ± 8.20 | 4.2 ± 1.0 | 19.4 ± 2.80 | 26.4 ± 5.15 | 53.0 ± 12.79 |
| 1 | 5.1 ± 0.43 | 47.1 ± 10.41 | 3.9 ± 0.90 | 22.6 ± 4.25 | 26.6 ± 3.88 | 65.7 ± 12.49 |
| 2 | 5.7 ± 0.45** | 59.4 ± 12.97 | 3.8 ± 0.47 | 23.6 ± 3.95 | 21.7 ± 5.28 | 50.9 ± 10.43 |
| WAY100635 | ||||||
| 0 | 6.2 ± 0.91 | 52.5 ± 9.57 | 7.0 ± 0.35 | 38.9 ± 11.37 | 24.8 ± 4.37 | 42.8 ± 5.74 |
| 2 | 5.6 ± 0.50 | 53.0 ± 8.06 | 5.1 ± 0.83 | 24.6 ± 4.40 | 26.8 ± 5.84 | 56.0 ± 15.64 |
| MDL11939 | ||||||
| 0 | 4.4 ± 0.62 | 45.6 ± 14.61 | 2.6 ± 0.58 | 18.9 ± 3.04 | 25.9 ± 3.91 | 57.5 ± 10.34 |
| 0.15 | 5.8 ± 0.55* | 68.1 ± 12.57* | 3.5 ± 0.67 | 26.7 ± 7.16 | 19.1 ± 2.44 | 35.4 ± 6.24* |
| 0.45 | 5.5 ± 0.40 | 50.2 ± 10.08 | 4.5 ± 0.46** | 24.7 ± 2.94 | 26.0 ± 2.15 | 53.5 ± 5.51 |
| Prazosin | ||||||
| 0 | 4.6 ± 0.42 | 50.5 ± 9.81 | 4.6 ± 0.75 | 26.0 ± 3.97 | 30.8 ± 4.61 | 45.3 ± 6.88 |
| 0.25 | 4.4 ± 0.48 | 56.0 ± 12.61 | 4.8 ± 0.25 | 26.3 ± 3.88 | 28.8 ± 3.35 | 41.8 ± 10.68 |
| B1 and B2 mixture | ||||||
| 0 | 5.0 ± 0.29 | 52.0 ± 10.46 | 4.4 ± 0.63 | 20.8 ± 3.86 | 30.8 ± 2.75 | 62.3 ± 11.39 |
| 1/1 | 4.6 ± 0.29 | 53.8 ± 7.81 | 3.1 ± 0.63 | 15.4 ± 1.90 | 25.0 ± 3.34** | 50.3 ± 8.38 |
Values represent mean ± SEM.
*p < 0.05,
**p < 0.01, compared with vehicle. All drug doses are in units of micrograms per 0.5 μl, except for muscimol dose, which is in units of nanograms per 0.5 μl.