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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Hypertension. 2011 May 2;57(6):1056–1057. doi: 10.1161/HYPERTENSIONAHA.111.173427

Figure 1.

Figure 1

Estrogen receptor-dependent protective effects of olmesartan in ischemia-induced brain injury in estrogen (E2)-deficient states such as menopause (natural or following ovariectomy). The angiotensin AT1 receptor antagonist olmesartan (Olm) increases expression and posphorylation of ERα. This results in up-regulation of the ACE2, Bcl-2 and Bcl-xL genes in an E2-independent manner, an effect that is blocked by the ERα antagonist ICI 182,780 (ICI). ICI also acts as an agonist of GPER. +, activation; -, inhibition.