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Preparation process and apparent solubility of nanosuspensions
| Media milling (minutes) | Apparent solubility after 72 hours (mg/mL) | |
|---|---|---|
| NPE1 | 0 | 10.37 |
| 5 | 12.54 | |
| 10 | 14.12a | |
| 15 | 13.91 | |
| 20 | 13.44 | |
| NPE2 | 10b | 17.18 |
Notes:
Selected for further studies;
Homogenized for 30 minutes following the milling process.
Abbreviations: NPE1, phenylephrine nanosuspension prepared by milling in a mannitol aqueous solution; NPE2, phenylephrine nanosuspension prepared by high pressure homogenization of NPE1.
