Effects of Tcf4 silencing by siRNA interference in HCECs cultured in CnT-20. A. Real-time PCR analysis showing the effects of siRNA-Tcf4 (10-50nM) transfection on mRNA expression of β-catenin, Tcf4 and survivin with untreated cells and transfected with non-coding sequence siRNA-F as controls, n=5; B. Western blot results showing the protein levels of β-catenin, Tcf4 and survivin after transfection with siRNA-Tcf4 or –F; C. WST-1 assay showing the cell proliferation indexes after siRNA-Tcf4 transfection. Data are shown the mean and standard deviation of results, ns: no significance, *p <0.05, **p <0.01, ***p <0.001, n=3, compared with siRNA-F transfection.