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Receiver operator characteristic (ROC) plots for models 1 and 2. A) Model 1, developed in and applied to all PLCO control subjects; B) model 1 applied to external validation dataset (PLCO intervention arm); C) model 2 developed in and applied to smokers in the PLCO control arm; D) model 2 applied to smokers in external validation set (PLCO intervention arm). PLCO = Prostate, Lung, Colorectal, Ovarian cancer screening trial.
