Table 1.
Anti-plasmodial activity and cytotoxicity of sub-extracts and fractions from H. lanceolatum
| Sub-extract or Fraction | IC50 on W2mef (μg/mL) | CC50 on LLC-MK2 cells (μg/mL) | Selectivity Index (SI) |
|---|---|---|---|
| MeOH crude extract | 3.98 ± 0.11 | > 1000 | - |
| Ethylacetate sub-extract | 5.02 ± 1.01 | 204.86 ± 2.00 | 40.80 ± 0.39 |
| Aqueous sub-extract | 15.48 ± 6.25 | 125 ± 0.00 | 8.07 ± 0.00 |
| n-butanol extract | 11.95 ± 5.81 | >1000 | - |
| F1 | 15.60 ± 1.35 | 46.87 ± 15.62 | 3.00 ± 1.00 |
| F2 | 6.37 ± 2.17 | 125 ± 0.00 | 19.62 ± 0.00 |
| F3 | 3.91 ± 0.01 | 250 ± 0.00 | 39.24 ± 0.00 |
| F4 | 5.33 ± 2.47 | 31.25 ± 0.00 | 5.86 ± 0.00 |
| F5 | 14.52 ± 0.46 | >1000 | - |
| QN | 0.27 ± 0.04 | - | - |
QN: Quinine