Table 3.
Cytotoxicity profile of H. Lanceolatum compounds
| Compound (code) | CC50 on LLC-MK2 (μg/mL) | Mean SI for W2mef | Mean SI for W2mef |
|---|---|---|---|
| HLT0 | 37.50 ± 6.25 | 7.48 | 6.27 |
| Betulinic acid (HLT1) | 25.00 ± 0.00 | 4.98 | 4.46 |
| 2,2',5,6'-Tetrahydroxybenzophenone (HLT2) | > 100 | - | - |
| 5-Hydroxy-3-methoxyxanthone (HLT3) | > 100 | - | - |
| 3-Hydroxy-5-methoxyxanthone (HLT4) | 12.50 ± 0.00 | 0.36 ± 0.00 | 0.36 |
Cytotoxicity was categorised as follows [15]: CC50 < 1.0 μg/ml (high cytotoxicity); CC50 1.0 -10.0 μg/ml (moderate); CC50 10.0-30.0 μg/ml (mild); and CC50 > 30 μg/ml (non toxic).