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Histopathological changes and virus gene expression in oral SCC xenografts in nude mice. Oral SCC xenografts in nude mice were given 1 × 106 PFUs of R849 (a, b), HF (c, d), or RH2 (e, f). Tumors with skin were removed 3 days after infection and subjected to immunohistochemical staining using antibody against HSV-1. Arrows indicate rounded cells (b) and multinucleated cells (d, f).
