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. 2011 Jul 7;7(7):e1002091. doi: 10.1371/journal.pgen.1002091

Figure 6. TNIP1 abrogates the profibrotic effects of proinflammatory cytokines on collagen synthesis by SSc fibroblatsts.

Figure 6

(A,B) SSc dermal fibroblasts treated with recombinant TNFa or IL1β and incubated 24 hours with TNIP1 displayed decreased mRNA levels for (A) COL1A1 (1.6 and 1.5-fold reduction, P = 0.02 and 0.04, respectively) and (B) COL1A2 (1.7 and 1.8-fold reduction, P = 0.02 and 0.009, respectively). No significant effect was observed in cells treated with recombinant IL6. (C) Collagen content in cell culture supernatants treated with TNFa or IL1β was also reduced upon treatment with TNIP1 (1.8 and 2.3-fold reduction, P = 0.04 and 0.03, respectively). * indicates a P<0.05 vs. SSc fibroblasts treated with recombinant TNFa. ** indicates a P<0.05 vs. SSc fibroblasts treated with recombinant IL1 β.