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. 2011 Jul 7;6(7):e21698. doi: 10.1371/journal.pone.0021698

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Feng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A total of 23 IA patients were treated with adefovir dipivoxil for 12 weeks and the frequency of TFH cells in peripheral blood was determined by flow cytometry analysis before and after treatment. (A) The percentage of CXCR5⁺CD4⁺ TFH cells in the total CD4⁺T cells; (B) The percentage of PD-1⁺CXCR5⁺CD4⁺ cells in total CXCR5⁺CD4⁺ cells. Data are expressed as mean % of individual patients who were drug responders (n = 15). The horizontal lines indicate the median values of different groups. (C) The correlation of the frequency of CXCR5⁺CD4⁺ cells with the amount of serum HBV DNA in drug-responding patients before drug treatment.