Figure 4.

36 homologous amino acid residues conserved in hPMS2, hPMS1 and hMLH3. The proportions of identity or similarity with residues 612–674 of hPMS2 are presented. Lowercase letters indicate positions of the heptad repeat in the predicted coiled-coil motif. Bold letters in the consensus sequence correspond to identical amino acids. X, non-conserved amino acids. As for hMLH3, four homologous regions were identified, however, only residues 860–895, the highest homologous region, can interact with hMLH1.