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. 2011 Jul 7;6(7):e21979. doi: 10.1371/journal.pone.0021979

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Sheridan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Histology of the liver of a 4 month-old Acox1^lampe1 mouse showing fat accumulation in a zonal distribution around the central veins (magnification 200×) and (b) scattered foci of lobular inflammation with aggregates of macrophages at 4 months (magnification 400×). (c) At 12 months, the liver architecture is markedly disrupted by expansile nodules replacing most of the parenchyma (magnification 200×). (d) Foci of dysplastic hepatocytes and dysplastic nodules were present throughout the liver and some of the nodules contained areas of frank hepatocellular carcinoma (e), with loss of reticulin fibers (f). Hematoxylin and eosin (a–e) and reticulin (f) stain. 6D–F 400× magnifications.