Table 2.

Frequency of infection

Frequency of infected CD4+ T cells
	Observed no. of HIV DNA molecules per row						Frequency of multiple infection		Method 1*		Method 2†
Patient	0	1	2	3	4	P value for null hypothesis of no multiple infection	Upper 95% confidence bound (%)	Most consistent with observed no. of multiple HIV DNA molecules (%)	Cells/HIV DNA	95% CI	Cells/HIV DNA	95% CI
Individual patients
Early Infection
1 (1)‡	94 (92.1)§	20 (22.4)	4 (4.4)	1 (0.9)	1 (0.2)	0.5	40.5	2.0	869	625–1,247	1,169	798–1,790
2 (1)	77 (79.3)	19 (14.5)	0 (1.9)	0 (0.2)	0 (0)	1.0	14.6	0	813	521–1,349	813	521–1,349
3 (1)	142 (140.5)	14 (17.2)	4 (2)	0 (0.2)	0 (0)	0.2	43.9	10	2,847	1,881–4,543	3,480	2,202–5,872
4 (1)	58 (61.4)	21 (15.1)	1 (2.9)	0 (0.6)	0 (0.1)	0.98	19.8	0	1,078	719–1701	1,127	745–1,798
5 (1)	119 (118)	15 (16.1)	1 (1.7)	1 (0.1)	0 (0)	0.56	32.6	0.9	3,532	2,287–5,782	4,155	2,595–7,133
Chronic Infection
6 (2)	65 (65.6)	20 (19.1)	3 (2.9)	0 (0.3)	0 (0)	0.25	30.4	4.9	954	651–1,460	1,078	719–1,701
	142 (139)	20 (25.4)	5 (3.2)	1 (0.3)	0 (0)		40.5		783	558–1,137	994	678–1,521
7 (2)	128 (122)	15 (24.9)	7 (4.2)	1 (0.7)	1 (0.1)	0.1	56.3	9.7	1,296	936–1,850	1,943	1,306–3,033
	88 (88.8)	20 (20.1)	4 (3.2)	0 (0.4)	0 (0)		34.2		666	461–1,002	777	522–1,212
8 (2)	99 (97.3)	10 (13.4)	3 (1.2)	0 (0.1)	0 (0)	0.14	49.5	10.4	1,465	902–2,563	1,803	1,055–3,368
	41 (37.4)	10 (14.8)	2 (3.2)	3 (0.5)	0 (0.1)		57.7		2,191	1,461–3,457	3,360	2,037–6,003
9 (1)	47 (47.6)	15 (14.1)	2 (2.1)	0 (0.2)	0 (0)	0.69	32.6	0	101	65–168	113	71–194
Combining all early and all chronic patients
Early Infection
	490 (491.3)	89 (85.3)	10 (12.9)	2 (2.0)	1 (0.3)	0.78	19.2	2.58	1,503¶		1,730
Chronic Infection
	610 (597.7)	110 (131.8)	26 (20.0)	5 (2.5)	1 (0.2)	0.03	29.1	7.0	617		771

*Method 1: Assuming no multiple infection.

^†Method 2: Assuming maximal multiple infection.

^‡Number of samples per patient in parentheses.

^§Poisson predicted values in parentheses.

^¶Geometric mean of early and chronic infection values.