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. 2011 Jun 20;108(27):11193–11198. doi: 10.1073/pnas.1019536108

Fig. 4.

Fig. 4.

miR-155−/− mice exhibit reduced development of T- and B-cell responses during CIA. Groups are as in Fig. 3. CII/miR-155−/− mice show (A) reduced systemic cytokine and chemokine concentrations and (B) reduced expression of TNF-α mRNA in articular tissue. (C and D) CII-miR-155−/− mice show a reduced differentiation of Th17 and Th1 cells in DLN. Representative staining (C) and quantitative evaluation (D) are shown. (E and F) miR-155 is required for the production of collagen-specific antibodies. Quantitative evaluation of antibody activity in isotypes IgG2a (E) and IgG1 (F) is shown. Data are means ± SEM, n = 15–17; *P < 0.05, miR-155−/− vs. WT mice (CIA protocol). CII, type II chicken collagen.