Fig. 2.

ALD-induced peritonitis in chimeras is codependent on IL-1R/MyD88 in radioresistant tissue and TLR4 in radiosensitive tissue. The chimera mice, MyD88/WT (A), C3H HeJ/HeOuJ (B), and IL-1R/WT (C) were injected intraperitoneally with vehicle (WT→WT n = 5, MyD88→WT n = 6, WT→MyD88 n = 6, and MyD88→MyD88 n = 4) or ALD (WT→WT n = 6, MyD88→WT n = 9, WT→MyD88 n = 11, MyD88→MyD88 n = 5, OuJ→OuJ n = 10, HeJ→HeJ n = 6, OuJ→HeJ n = 7, HeJ→OuJ n = 9, IL-1R→WT n = 5, and WT→IL-1R n = 8). The peritoneal cells were harvested, counted, and neutrophils were quantified 3 d after ALD injection. Data are means + SEM pooled from at least two independent experiments. *P < 0.05 by one-way ANOVA with Dunnett's post hoc test (A and B) or Mann-Whitney test (C).