Table 1.

Alendronate-induced peritonitis is dependent upon IL-1R and MyD88

	PBS				ALD
Treatment Strain	N	Total cell (×106)	Neutrophils (×105)	Monocytes (×106)	N	Total cell (×106)	Neutrophils (×105)	Monocytes (×106)
WT	10	2.62 ± 0.18	0.20 ± 0.05	1.96 ± 0.12	12	22.1 ± 3.8	89.3 ± 19.8	11.5 ± 1.9
Tlr7−/−	9	4.74 ± 0.65	0.58 ± 0.23	3.61 ± 0.53	9	17.9 ± 1.4	78.5 ± 9.4	9.2 ± 0.6
Tlr9−/−	9	3.06 ± 0.41	0.41 ± 0.2	2.38 ± 0.33	9	17.8 ± 2.6	78.6 ± 17.3	8.5 ± 1.1
Myd88−/−	6	1.98 ± 0.54	0.24 ± 0.14	1.48 ± 0.38	9	5.1 ± 1.3*	1.4 ± 0.6*	3.0 ± 0.7*
Il1r−/−	6	3.59 ± 0.22	1.31 ± 0.15	2.65 ± 0.14	7	14.6 ± 2.3	24.4 ± 6.4*	9.9 ± 1.7

Data shown are mean ± SEM pooled from two to three independent experiments. N: number of mice. Values in bold letters in ALD group are P < 0.02 compared with corresponding PBS group by Mann-Whitney test. *P < 0.001 compared with ALD treated WT group by one-way ANOVA with Dunnett's post hoc test.