Table 2.

Alendronate-induced peritonitis is dependent upon TLR4 signaling

	PBS				ALD
Treatment Strain	N	Total cell (×106)	Neutrophils (×105)	Monocytes (×106)	N	Total cell (×106)	Neutrophils (×105)	Monocytes (×106)
WT	7	1.79 ± 0.18	0.14 ± 0.06	1.79 ± 0.18	8	7.3 ± 0.5	64.6 ± 6.8	7.3 ± 0.5
Tlr4−/−	7	0.75 ± 0.15	0.03 ± 0.02	0.75 ± 0.15	10	5.6 ± 0.6*	27.3 ± 2.6*	5.6 ± 0.6*
C3H HeOuJ	5	4.08 ± 0.95	0.45 ± 0.15	3.21 ± 0.75	7	22.5 ± 2.2	109.3 ± 9.1	11.5 ± 1.2
C3H HeJ	5	4.04 ± 0.46	0.28 ± 0.18	2.98 ± 0.39	8	9.7 ± 2.6*	23.1 ± 7.4*	6.8 ± 1.8*

Data shown are mean ± SEM pooled from two to three independent experiments. N: number of mice. Values in bold letters in ALD group are P < 0.005 compared with corresponding PBS group by Mann-Whitney test. *P < 0.001 compared with ALD treated WT group (WT vs. TLR4^−/−, and C3H HeOuJ vs. C3H HeJ, respectively) by one-way ANOVA with Dunnett's post hoc test.