Table 1. List of eukaryotic proteins with a predicted myxococcal origin.
| Biological function | Symbol | Support (BV/PP) | Localization | Mitochondria-targeting signal peptide | ||
| Lipid metabolism | Acyl-CoA synthetase | ACSF3 | 100/1 | Mitochondria | Aspergillus, Capsaspora, Metazoa, Trypanosomatids | |
| Lipid metabolism | Acyl-CoA synthetase (EC:6.2.1.3) | ACSBG1ACSBG2 | 56/0.57 | Cytosol | none | |
| Lipid metabolism | Fatty-acid β-oxidation | Acyl-CoA dehydrogenase (EC:1.3.99.3) | ACADM | 70/0.84 | Mitochondria | Capsaspora, Metazoa, Phytopthora, Trypanosomatids |
| Lipid metabolism | Fatty-acid β-oxidation | Acyl-CoA dehydrogenase (EC:1.3.99.2) | ACADS | 72/1 | Mitochondria | Capsaspora, Metazoa |
| Lipid metabolism | Fatty-acid β-oxidation | Acyl-CoA dehydrogenase (EC:1.3.99.12) | ACADSB | 78/1 | Mitochondria | Capsaspora, Cyanidioschyzon, Fungi, Metazoa, Phaeodactylum, Trypanosomatids |
| Lipid metabolism | Fatty-acid β-oxidation | Acyl-CoA dehydrogenase (EC:1.3.99.-) | ACADVL ACAD9 | 96/0.98 | Mitochondria | Capsaspora, Metazoa |
| Lipid metabolism | Fatty-acid β-oxidation | Electron-transfer- flavoprotein | ETFA | 95/0.99 | Mitochondria | Archaeplastida, Capsaspora, Dictyostelium, Excavata, Metazoa |
| Lipid metabolism | Fatty-acid β-oxidation | Acyl-CoA acyltransferase (EC:2.3.1.16) | ACAA2 | 77/0.98 | Mitochondria | Capsaspora, Fungi, Metazoa |
| Lipid metabolism | Ceramidase (EC:3.5.1.23) | ASAH2 | 100/0.91 | Mitochondria | none | |
| Proteases | Metallopeptidase M3 family (EC:3.4.24.15/3.4.24.16) | NLN THOP1 | 100/1 | Mitochondria and cytosol | Archaeplastida, Capsaspora, Fungi, Metazoa, Trypanosomatids | |
| Proteases | Aminopeptidase (EC:3.4.11.-) | NPEPL1 | 100/1 | ??? | none | |
| Amino acid metabolism | Aminobutyrate aminotransferase (EC:2.6.1.19/2.6.1.22) | ABAT | 95/1 | Mitochondria | Capsaspora, Dictyostelium, Fungi, Metazoa | |
| Translational system | Translation elongation factor | GFM1 | 92/0.66 | Mitochondria | Capsaspora, Metazoa, Trypanosomatids | |
| TCA cycle | NAD(+) dependent isocitrate dehydrogenase (EC:1.1.1.41) | IDHA3A IDHA3B IDHA3G | 73/0.99 | Mitochondria | Archaeplastida, Capsaspora, Dictyostelium, Fungi, Metazoa | |
| tRNA synthesis | Arginyl tRNA synthetase (EC:6.1.1.19) | RARS2 | 75/0.99 | Mitochondria | Capsaspora, Fungi, Metazoa | |
Symbol corresponds to the human annotation as found in NCBI. Support indicates the statistical support for a monophyletic myxococcal+eukaryotic group as obtained from the 1000-replicate ML bootstrap values (BV, in %) and the Bayesian posterior probability (PP). Localization indicates the localization determined for most of the studied eukaryotes. Taxa shown in the last column are the eukaryotes in which the TargetP program (http://www.cbs.dtu.dk/services/TargetP/) [52] detected a putative mitochondria-targeting peptide. When generic lineage names, such as Archaeplastida, Excavata, Fungi, Metazoa or Trypanosomatids, are shown, at least two different species of this group were found to have a predicted signal peptide.