Table 2. Association between the ESR1 (6q25) locus and QUS eBMD and DXA BMD_a.

SNP	Chr position	Base change	MAF	Total hip BMDa		Lumbar spine BMDa		Calcaneal eBMD
				β (95%CI)	p-value	β (95%CI	p-value	β (95%CI	p-value
rs9479055	151889660	A→C	0.41	−0.03 (−0.13, 0.07)	0.565	−0.01 (−0.12, 0.10)	0.848	−0.05 (−0.10, 0.01)	0.080
rs4463269	151903921	C→T	0.30	−0.00 (−0.11, 0.11)	0.957	−0.01 (−0.13, 0.11)	0.829	−0.01 (−0.07, 0.05)	0.637
rs3757317	151907224	C→T	0.15	−0.14 (−0.27, −0.01)	0.036	−0.09 (−0.23, 0.05)	0.221	−0.06 (−0.13, 0.02)	0.140
rs4869738	151933844	G→T	0.24	0.01 (−0.11, 0.12)	0.935	−0.02 (−0.15, 0.10)	0.714	−0.03 (−0.09, 0.04)	0.405
rs4870044	151943102	C→T	0.28	−0.12 (−0.23, −0.02)	0.021	−0.05 (−0.17, 0.06)	0.371	−0.10 (−0.15, −0.04)	0.002
rs1038304	151974868	A→G	0.49	−0.15 (−0.25, −0.05)	0.003	−0.11 (−0.22, −0.003)	0.045	−0.08 (−0.13, −0.02)	0.004
rs6929137	151978370	G→A	0.31	−0.13 (−0.24, −0.03)	0.013	−0.08 (−0.20, 0.03)	0.152	−0.05 (−0.11, 0.01)	0.131
rs1999805	152110057	T→C	0.41	−0.14 (−0.24, −0.05)	0.004	−0.12 (−0.23, −0.02)	0.026	−0.11 (−0.16, −0.05)	0.0001

β, effect estimates are shown as standardized values (standard deviations above or below the population average) for each copy of the minor allele adjusted for height and weight.